Donate
Ataxia, Cerebellar, Neonatal, GRM1-related
Breed: Coton de Tulear
Generic Phene Data
Breeds
Relevance Rating: There is moderate evidence or research available for these breeds
Relevance Rating: There is some evidence or research available in this breed
General
Disease Name
Ataxia, Cerebellar, Neonatal, GRM1-related
OMIA
78
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Mutation 2
c.1972T>C
Mutation 3
c.2331_2332ins62bp
Test Type
Genetic Disease/Disorder
Details
Ataxia seems to come in breed-related, or breed-specific types. Puppies appear to have a normal mental status, but with eye tremors, nodding from the head, body tremors, and severe gait effects. Most affected puppies are unable to stand and use "swimming" movements. Age of onset from around 2 weeks. The condition was nonprogressive at least until 4 months of age.
Details 2
Symptoms include normal mental status, head titubation, intention tremors, and severe gait, stance, and ocular ataxia beginning at 2 weeks of age. Affected pups are unable to stand and used propulsive movements (??swimming??), with frequent falling to lateral recumbency with subsequent decerebellate posturing and paddling. Ocular motor abnormalities included fine vertical tremors at rest and saccadic dysmetria. The condition was nonprogressive at least until 4 months of age. (from Coates et al. 2002)
Published
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 coding sequence in Coton de Tulear dogs with Bandera?s neonatal ataxia. J Vet Intern Med 25:267-72, 2011. Pubmed reference: 21281350. DOI: 10.1111/j.1939-1676.2010.0666.x
Published 2
Coates, J.R., O'Brien, D.P., Kline, K.L., Storts, R.W., Johnson, G.C., Shelton, G.D., Patterson, E.E., Abbott, L.C. : Neonatal cerebellar ataxia in Coton de Tulear dogs Journal of Veterinary Internal Medicine 16:680-9, 2002. Pubmed reference: 12465765.
Body/System/Process
Neurologic
OMIA Url
Inheritance
AR
Breed Specific Info
Researched Breeds
Coton de Tulear
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Antagene
GTP
GTP Name
Antagene
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Nature of test
mutation test
GTP- or Breed-Specific Publications
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 c
Application in the Breed
Carriers may be bred to normal animals (N/bnat x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/bnat x N/bnat) nor of affected animals (bnat/bnat). Neonatal ataxia (cerebellum). Unable to walk, falling over.. Tremors in the eye. Very poor quality of life.
Inheritance
AR
FCI Number
283
GTP Breed
Coton de Tulear
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Nature of test
mutation test
GTP- or Breed-Specific Publications
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 c
Application in the Breed
Carriers may be bred to normal animals (N/bnat x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/bnat x N/bnat) nor of affected animals (bnat/bnat). Neonatal ataxia (cerebellum). Unable to walk, falling over.. Tremors in the eye. Very poor quality of life.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
283
GTP Breed
Coton de Tulear
Embark
GTP
GTP Name
Embark
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Nature of test
mutation test
GTP- or Breed-Specific Publications
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 c
Application in the Breed
Carriers may be bred to normal animals (N/bnat x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/bnat x N/bnat) nor of affected animals (bnat/bnat). Neonatal ataxia (cerebellum). Unable to walk, falling over.. Tremors in the eye. Very poor quality of life.
Inheritance
AR
GTP Notes
Awaiting validation
FCI Number
283
GTP Breed
Coton de Tuleur
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
Bandera´s neonatal ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Mutation Comment
a 62-bp truncated retrotransposon insert in exon 8
Nature of test
mutation test
Inheritance
AR
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
GTP- or Breed-Specific Publications
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 c
Application in the Breed
Carriers may be bred to normal animals (N/bnat x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/bnat x N/bnat) nor of affected animals (bnat/bnat). Neonatal ataxia (cerebellum). Unable to walk, falling over.. Tremors in the eye. Very poor quality of life.
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Nature of test
mutation test
GTP- or Breed-Specific Publications
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 c
Application in the Breed
Carriers may be bred to normal animals (N/bnat x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/bnat x N/bnat) nor of affected animals (bnat/bnat). Neonatal ataxia (cerebellum). Unable to walk, falling over.. Tremors in the eye. Very poor quality of life.
Inheritance
AR
FCI Number
283
GTP Breed
Coton de Tulear
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Nature of test
mutation test
Inheritance
AR
FCI Number
283
GTP Breed
Coton de Tulear
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
Neonatal Ataxia
GTP Disease Synonym
Cerebellar Ataxia
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
Nature of test
mutation test
GTP- or Breed-Specific Publications
Zeng, R., Farias, FH., Johnson, GS., McKay, SD., Schnabel, RD., Decker, JE., Taylor, JF., Mann, CS., Katz, ML., Johnson, GC., Coates, JR., O?Brien, DP.: A truncated retrotransposon disrupts the GRM1 c
Application in the Breed
Carriers may be bred to normal animals (N/bnat x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/bnat x N/bnat) nor of affected animals (bnat/bnat). Neonatal ataxia (cerebellum). Unable to walk, falling over.. Tremors in the eye. Very poor quality of life.
Inheritance
AR
FCI Number
283
GTP Breed
Coton de Tulear
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
GRM1
Mutation
c.2331_2332ins62bp
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
-
HGTD Quick Search
-
The portal for Genetic Testing Providers (labs); genetic tests, and tests by breed: as well as information on quality indicators and genetic counseling resources.
GOAL: Robust genetic testing supporting health improvements & a sustainable future for healthy dogs. -
HGTD Database Resources
How to use the HGTD
Using HGTD - YouTube Videos
HGTD Quality Indicators
Acronyms - Mode of Inheritance♦ 2020-New What is a Relevance Rating?
FAQs
Answers to frequently asked questions about the HGTD
Accreditation Basics
This brief overview may help you identify what types of accreditation are important to you, when choosing your genetic test provider.
Accreditation and Industry Standards
List of organizations throughout the world that are involved in matters of accreditation and establishing industry standards.
Choosing a Genetic Test Provider
Choosing a genetic test provider can be daunting. This short article helps you to consider what is important to you, and your dogs, in finding the right test provider for you. -
The HGTD's genetic counselling resources index provides access to basic introductory articles on genetics, articles on application of genetics in breed health management, and advanced work in technical genetics research. Breed-specific information is also available in our Pedigreed Dogs Database.
