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Leukocyte Adhesion Deficiency III (LAD3)


Relevance Rating: There is some evidence or research available in this breed

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds


Disease Name
Leukocyte Adhesion Deficiency III (LAD3)
Gene Name 2
Mutation 2
Test Type
Genetic Disease/Disorder
Leukocyte Adhesion Deficiency III (LAD3) is considered a rare disease. Symptoms include: increased risk of infections, fever, lameness, and abnormal bleeding, including hemorrhage.
Details 2
Leucocyte adhesion deficiencies are inherited disorders characterised by immunodeficiency leading to recurrent infections and a marked leucocytosis. We describe the clinical characteristics... dog was investigated for pyrexia, persistent leucocytosis, marked periodontal disease, lameness, increased mucosal haemorrhages and poor wound healing. Numerous diagnostics were performed including a leucocyte adhesion deficiency III PCR test, which was positive... Leucocyte adhesion deficiency III is a rare disorder that manifests because of impaired activation of beta integrins. This results in an absence of neutrophil chemotaxis and adhesion, and platelet dysfunction... (From Hugo and Heading, 2014)
Boudreaux, Mary K., et al. "A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections." Thrombosis and haemostasis 103.2 (2010): 475-477.
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