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Neonatal Encephalopathy with Seizures

Breed: Poodle/ standard

Generic Phene Data

Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
GTPs
Agrotis S.r.l.
Antagene
BioBank AS
Certagen GmbH
CMSCH
DNA My Dog
Embark
EVG Diagnostics
Genomia s.r.o
GenSol Diagnostics
INNO
Laboklin Gmbh & Co. KG
Laboratorios Labocor S.L.
Orivet Genetic Pet Care
Orthopedic Foundation for Animals
Paw Print Genetics
PharmaDNA
Progènes-ADN
Veterinary Genetics Laboratory
VetGen LLC
VHL Genetics
Weatherbys Scientific
Wisdom Panel - Kinship
Zoolyx
AnimaLabs

General

Disease Name
Neonatal Encephalopathy with Seizures
OMIA
1471
Gene Name
ATF2
Mutation
c.152T>G
Test Type
Genetic Disease/Disorder
Details
Puppies affected by Neonatal Encephalopathy with Seizures are small at birth and do not develop normally - initially struggling to nurse. Nursing improves after several days, but at around 3 weeks of age, signs include: weakness, ataxia, whole-body tremors, wide-based stance, and muscle weakness. Pups do not interact normally with the dam or littermates and have slow responses to stimulation. Sympotoms change at 4 to 6 weeks of age to include generalized seizures. Pups usually die or are euthanized by 7 weeks of age.
Details 2
Affected puppies are small at birth and do not develop normally. They initially nurse poorly, but begin nursing sufficiently after several days... At approximately 3 weeks of age, weakness, ataxia, whole-body tremors, wide-based stance with increased extensor tone, and axial muscle weakness with neck ventroflexion is observed. Affected pups do not interact with the dam or littermates and have slow responses to external stimuli... At approximately 4 to 6 weeks of age, affected puppies develop generalized clonic-tonic seizures that quickly become refractory to treatment. They become laterally recumbent with extensor rigidity and opisthotonus, and usually die or are euthanized before 7 weeks of age (Chen et al., 2008).
Published
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. Neurogenetics 9:41-9, 2008. Pubmed reference: 18074159. DOI: 10.1007/s10048-007-0112-2.
Body/System/Process
Neurologic
Inheritance
AR

Breed Specific Info

Researched Breeds
Standard Poodles
Breed-specific 1
Standard Poodles
Breed-specific 1 Details
2008 Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. Neurogenetics 9:41-9, 2008. Pubmed reference: 18074159. DOI: 10.1007/s10048-007-0112-2.
Breed-specific 2
Goldendoodle
Breed-specific 2 Details
Note that the Breed Relevance Rating for Goldendoodles only applies to crosses of Golden Retriever X Standard Poodles, not necessarily any poodle variety.

HSP Test-Specific Data

AnimaLabs

GTP
GTP Name
AnimaLabs
Breed
OMIA

Zoolyx

GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

Wisdom Panel - Kinship

GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Standard Poodle

Weatherbys Scientific

GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

VHL Genetics

GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

VetGen LLC

GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

Veterinary Genetics Laboratory

GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen X, GS Johnson, RD Schnabel, JF Taylor, GC Johnson, HG Parker, EE Patterson, ML Katz, T Awano, S Khan, DP O?Brien. 2008. A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. Neurogene
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Standard Poodle

Progènes-ADN

GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

Paw Print Genetics

GTP
GTP Name
Paw Print Genetics
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
FCI Number
172
GTP Breed
Poodle/ Standard

Orivet Genetic Pet Care

GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Standard Poodle

Orthopedic Foundation for Animals

GTP
GTP Name
Orthopedic Foundation for Animals
Breed
OMIA
Gene Name
Gene not yet published
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Poodle/ Standard

Laboklin Gmbh & Co. KG

GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Poodle/ Standard

Laboratorios Labocor S.L.

GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

INNO

GTP
GTP Name
INNO
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

GenSol Diagnostics

GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.

Genomia s.r.o

GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Mutation Comment
g.19078954A>C
Nature of test
mutation test
FCI Number
172
GTP Breed
Poodle/ Standard

EVG Diagnostics

GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

Embark

GTP
GTP Name
Embark
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Standard Poodle

DNA My Dog

GTP
GTP Name
DNA My Dog
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
172
GTP Breed
Standard Poodle

CMSCH

GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

Certagen GmbH

GTP
GTP Name
Primary Lens Luxation (PLL)
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

BioBank AS

GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G

Antagene

GTP
GTP Name
Antagene
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle
Application in the Breed
Carriers may be bred to normal animals (N/news x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/news x N/news) .Born smaller and fail to nurse normally. Weakness, trouble moving, whole-body tremors (3 weeks of age). Clonic-tonic seizures ( 4-6 weeks of age) - fdeath around 7 weeks of age.
Inheritance
AR
FCI Number
172
GTP Breed
Standard Poodle

Agrotis S.r.l.

GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
ATF2
Mutation
c.152T>G
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