Piebald, Extreme White Spotting
Breed: ALL
Generic Phene Data
Breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Piebald, Extreme White Spotting
OMIA
214
Gene Name
MITF
Mutation
three possible regulatory variants
Test Type
Other Genetic Traits
Details
Piebald, or Extreme White Spotting describes a variable degree of white spotting ranging from tiny white spots up to completely white animals. Effects range from completely white coat, to "Irish spotting" (white collar and belly) , and Piebald.
Details 2
Piebald, or Extreme White Spotting describes a variable degree of white spotting ranging from tiny white spots up to completely white animals. The absence of pigment is caused by the absence of skin melanocytes ("leucism"), not by failure in the biochemical reactions required for pigment synthesis. As summarised by Körberg et al. (2014), Little "described four different alleles at this locus with phenotypic effects ranging from solid (S, . . .), to a completely white coat, caused by homozygosity for the Extreme white allele (sw, . . .). The two intermediate phenotypes were named Irish spotting (si, . . .) and piebald (sp, . . .). Irish spotting is characterized by modest white spotting, often present as a white collar and a white belly, as demonstrated by breeds such as the Bernese Mountain dog and Basenji. Piebald-coloured dogs display limited to extensive white spotting and the phenotype is observed in several breeds, including the Beagle and Fox Terrier." (From OMIA)
Published
Leegwater, PA., van Hagen, MA., van Oost, BA. : Localization of white spotting locus in Boxer dogs on CFA20 by genome-wide linkage analysis with 1500 SNPs. J Hered 98:549-52, 2007. Pubmed reference: 17548862. DOI: 10.1093/jhered/esm022.
Published 2
Baranowska Körberg, I., Sundström, E., Meadows, J.R., Rosengren Pielberg, G., Gustafson, U., Hedhammar, Å., Karlsson, E.K., Seddon, J., Söderberg, A., Vilà, C., Zhang, X., Åkesson, M., Lindblad-Toh, K., Andersson, G., Andersson, L. : A simple repeat polymorphism in the MITF-M promoter is a key regulator of white spotting in dogs. PLoS One 9:e104363, 2014. Pubmed reference: 25116146. DOI: 10.1371/journal.pone.0104363.
Body/System/Process
Coat Colour/Pattern/Type
OMIA Url
Inheritance
A
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
GTP Disease Name
S Locus (White Spotting, Parti, or Piebald)
Gene Name
MITF
Mutation
Deletion
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
MITF
Mutation Comment
g.21836232_21836427delinsN[198]
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
S Locus (White Spotting, Parti, or Piebald)
Gene Name
MITF
Mutation
Deletion
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
S Locus (White Spotting, Parti, or Piebald)
Gene Name
MITF
Mutation
Deletion
Nature of test
mutation test
FCI Number
-20
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
S Locus (White Spotting, Parti, or Piebald)
Gene Name
MITF
Mutation
Deletion
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
MITF
Mutation
Deletion
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA