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Polyneuropathy - NDRG1 Type (AMPN)
Breed: Greyhound
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Polyneuropathy - NDRG1 Type (AMPN)
OMIA
2120
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Mutation 2
c.293G>T
Mutation 3
Gly98Val
Test Type
Genetic Disease/Disorder
Details
Polyneuropathy describes many abnormalities of the nervous system including sensory nerves, motor nerves, and autonomic nerves. Signs include progressive weakness, exercise intolerance, high-steppage, change in bark pitch and difficulty breathing. Age of onset 7 to 20 months of age. Symptoms can be progressive.
Published
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010. Pubmed reference: 20582309. DOI: 10.1371/journal.pone.0011258.
Published 2
Bruun, C.S., Juderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerkas, I., Stigen, O., Espenes, A., Rohdin, C., Edlund, R., Ohlsson, J., Cizinauskas, S., Leifsson, P.S., Drogemuller, C., Moe, L., Cirera, S., Fredholm, M. : A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS One 8:e54547, 2013. Pubmed reference: 23393557. DOI: 10.1371/journal.pone.0054547.
Body/System/Process
Neurologic
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
158
GTP Breed
Greyhound
Embark
GTP
GTP Name
Embark
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
GTP- or Breed-Specific Publications
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
158
GTP Breed
Greyhound
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
GTP- or Breed-Specific Publications
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
158
GTP Breed
Greyhound
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
FCI Number
158
GTP Breed
Greyhound
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Nature of test
mutation test
FCI Number
158
GTP Breed
Greyhound
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
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