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Polyneuropathy - NDRG1 Type (AMPN)
Breed: Alaskan Malamute
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
GTPs
General
Disease Name
Polyneuropathy - NDRG1 Type (AMPN)
OMIA
2120
Gene Name
NDRG1
Mutation
c.1080_1089delTCGCCTGGAC
Mutation 2
c.293G>T
Mutation 3
Gly98Val
Test Type
Genetic Disease/Disorder
Details
Polyneuropathy describes many abnormalities of the nervous system including sensory nerves, motor nerves, and autonomic nerves. Signs include progressive weakness, exercise intolerance, high-steppage, change in bark pitch and difficulty breathing. Age of onset 7 to 20 months of age. Symptoms can be progressive.
Published
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010. Pubmed reference: 20582309. DOI: 10.1371/journal.pone.0011258.
Published 2
Bruun, C.S., Juderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerkas, I., Stigen, O., Espenes, A., Rohdin, C., Edlund, R., Ohlsson, J., Cizinauskas, S., Leifsson, P.S., Drogemuller, C., Moe, L., Cirera, S., Fredholm, M. : A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS One 8:e54547, 2013. Pubmed reference: 23393557. DOI: 10.1371/journal.pone.0054547.
Body/System/Process
Neurologic
OMIA Url
Inheritance
AR
HSP Test-Specific Data
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
243
GTP Breed
Alaskan Malamute
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
University of Minnesota Canine Genetics Lab
GTP
GTP Name
University of Minnesota Canine Genetics Lab
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy
Gene Name
NDRG1
Mutation
Gly98Val
Mutation Comment
Gly98Val
Application in the Breed
A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. Bruun CS, Jäderlund KH, Berendt M, Jensen KB, Spodsberg EH, Gredal H, et al. (2013), PLoS ONE 8(2): e54547.doi:10.1371/journal.pone.0054547
FCI Number
243
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun CS, KH Jäderlund, M Berendt et al. 2013. A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS ONE 8(2): e54547. doi:10.1371/journal.pone.0054547.
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
243
GTP Breed
Alaskan Malamute
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
FCI Number
243
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
243
GTP Breed
Alaskan Malamute
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
243
GTP Breed
Alaskan Malamute
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
Embark
GTP
GTP Name
Embark
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
243
GTP Breed
Alaskan Malamute
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
243
GTP Breed
Alaskan Malamute
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
Antagene
GTP
GTP Name
Antagene
Breed
OMIA
GTP Disease Name
Alaskan Malamute Polyneuropathy, AMPN
Gene Name
NDRG1
Mutation
c.293G>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerk
Application in the Breed
Carriers can be bred to normal animals (N/p x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/p x N/p) nor affected animals (p/p) .Chronic, progressive disease with clinical signs between 7-18 months of age. Symptoms: exercise intolerance , gait abnormalities l --> para- or tetraparesis, muscle atrophy, laryngeal paralysis.
Inheritance
AR
FCI Number
243
GTP Breed
Alaskan Malamute
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
NDRG1
Mutation
c.293G>T
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