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Primary Open Angle Glaucoma (POAG) ADAMTS10
Breed: Beagle
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
General
Disease Name
Primary Open Angle Glaucoma (POAG) ADAMTS10
OMIA
1870
Gene Name
ADAMTS10
Mutation
g.53101896G>A
Mutation 2
p.G661R
Mutation 3
c.1981G>A
Mutation 4
c.del2986_2991
Mutation Notes
mutations are breed-specific
Test Type
Genetic Disease/Disorder
Details
Primary open angle glaucoma, also known as POAG, is a painful condition where the pressure in the eye(s) increases over time eventually leading to blindness.
Details 2
Primary open angle glaucoma, also known as POAG, is a painful condition where the pressure in the eye(s) increases over time eventually leading to blindness.
Published
Kuchtey, J., Olson, L.M., Rinkoski, T., Mackay, E.O., Iverson, T.M., Gelatt, K.N., Haines, J.L., Kuchtey, R.W. : Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet 7:e1001306, 2011. Pubmed reference: 21379321. DOI: 10.1371/journal.pgen.1001306.
Published 2
Ahonen, Saija & Kaukonen, Maria & Nussdorfer, Forrest & D Harman, Christine & Komaromy, Andras & Lohi, Hannes. (2014). A Novel Missense Mutation in ADAMTS10 in Norwegian Elkhound Primary Glaucoma. PloS one. 9. e111941. 10.1371/journal.pone.0111941.
Body/System/Process
Eye
OMIA Url
Inheritance
AR
Breed Specific Info
Researched Breeds
Beagle, Norwegian Elkhound
HSP Test-Specific Data
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kuchtey, J., Olson, L.M., Rinkoski, T., Mackay, E.O., Iverson, T.M., Gelatt, K.N., Haines, J.L., Kuchtey, R.W. : Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a c
Application in the Breed
Carriers may be bred to normal animals (N/poag x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/poag x N/poag) nor of affected animals (poag/poag). Increase of pressure within the eye, eventually leading to blindness
Inheritance
AR
FCI Number
161
GTP Breed
Beagle
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kuchtey J, Olson LM, Rinkoski T, Mackay EO, Iverson TM, Gelatt KN, Haines JL, Kuchtey RW. 2011. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genetics. Feb;7(2):e1001
Application in the Breed
Nerve damage and vison loss
Inheritance
AR
FCI Number
161
GTP Breed
Beagle
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Nature of test
mutation test
FCI Number
161
GTP Breed
Beagle
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Nature of test
mutation test
FCI Number
161
GTP Breed
Beagle
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Mutation Comment
g.53096339C>T
Nature of test
mutation test
FCI Number
161
GTP Breed
Beagle
Embark
GTP
GTP Name
Embark
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kuchtey, J., Olson, L.M., Rinkoski, T., Mackay, E.O., Iverson, T.M., Gelatt, K.N., Haines, J.L., Kuchtey, R.W. : Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a c
Application in the Breed
Carriers may be bred to normal animals (N/poag x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/poag x N/poag) nor of affected animals (poag/poag). Increase of pressure within the eye, eventually leading to blindness
Inheritance
AR
FCI Number
161
GTP Breed
Beagle
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
ADAMTS10
Mutation
c.1981G>A
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