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Protein Losing Nephropathy
Breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Protein Losing Nephropathy
OMIA
1326
Gene Name
NPHS1
Gene Name 2
KIRREL2
Mutation
N1:c.3067G>A
Mutation 2
K2:c.1877C>G
Test Type
Genetic Disease/Disorder
Details
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Details 2
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Published
Littman, M.P., Wiley, C.A., Raducha, M.G., Henthorn, P.S. : Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mamm Genome 24:119-26, 2013. Pubmed reference: 23325127. DOI: 10.1007/s00335-012-9445-8.
Published 2
Lennon, E.M., Hanel, R.M., Walker, J.M., Vaden, S.L. : Hypercoagulability in dogs with protein-losing nephropathy as assessed by thromboelastography. J Vet Intern Med 27:462-8, 2013. Pubmed reference: 23528002. DOI: 10.1111/jvim.12067.
Body/System/Process
Renal
OMIA Url
Inheritance
unknown
Breed Specific Info
Researched Breeds
Soft Coated Wheaten Terrier
