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Protein Losing Nephropathy
Breed: Irish Soft Coated Wheaten Terrier
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Protein Losing Nephropathy
OMIA
1326
Gene Name
NPHS1
Gene Name 2
KIRREL2
Mutation
N1:c.3067G>A
Mutation 2
K2:c.1877C>G
Test Type
Genetic Disease/Disorder
Details
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Details 2
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Published
Littman, M.P., Wiley, C.A., Raducha, M.G., Henthorn, P.S. : Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mamm Genome 24:119-26, 2013. Pubmed reference: 23325127. DOI: 10.1007/s00335-012-9445-8.
Published 2
Lennon, E.M., Hanel, R.M., Walker, J.M., Vaden, S.L. : Hypercoagulability in dogs with protein-losing nephropathy as assessed by thromboelastography. J Vet Intern Med 27:462-8, 2013. Pubmed reference: 23528002. DOI: 10.1111/jvim.12067.
Body/System/Process
Renal
OMIA Url
Inheritance
unknown
Breed Specific Info
Researched Breeds
Soft Coated Wheaten Terrier
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
PLN in SCWT
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
Nature of test
mutation test
FCI Number
40
GTP Breed
Irish Soft Coated Wheaten Terrier
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
PLN in SCWT
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
Nature of test
mutation test
FCI Number
40
GTP Breed
Irish Soft Coated Wheaten Terrier
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
NPHS1 and KIRREL2
Mutation
N1:c.3067G>A; K2:c.1877C>G
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
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