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Trapped Neutrophil Syndrome (TNS)
Breed: Border Collie
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
GTPs
General
Disease Name
Trapped Neutrophil Syndrome (TNS)
OMIA
1428
Gene Name
VPS13B
Gene Name 2
CanFam3.1, Chr. 13
Mutation
g.4411950_4411953delGTTT
Mutation 2
g.1412654_1412657del
Mutation 3
c.2893_2896del
Test Type
Genetic Disease/Disorder
Details
Trapped Neutrophil Syndrome (TNS) is a mutation causing the dog's infection-fighting white blood cells to not be released from the bone marrow. The dog's immune system is unable to fight off infections and the dog eventually dies, usually when they are a few months old. Age of onset from birth, but symptoms may not be apparent until 7 months. An affected puppy may not show any specific symptoms, other than susceptibility to infection, but may be smaller and less healthy than unaffected puppies.
Details 2
Trapped Neutrophil Syndrome (TNS) is a mutation causing the dog's infection-fighting white blood cells to not be released from the bone marrow. The dog's immune system is unable to fight off infections and the dog eventually dies, usually when they are a few months old. Age of onset from birth, but symptoms may not be apparent until 7 months. An affected puppy may not show any specific symptoms, other than susceptibility to infection, but may be smaller and less healthy than unaffected puppies.
Published
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Published 2
Mizukami, K., Yabuki, A., Kawamichi, T., Chang, H.S., Rahman, M.M., Uddin, M.M., Kohyama, M., Yamato, O. : Real-time PCR genotyping assay for canine trapped neutrophil syndrome and high frequency of the mutant allele in Border collies. Vet J 195:260-1, 2013. Pubmed reference: 22795605. DOI: 10.1016/j.tvjl.2012.06.014.
Published 3
Mizukami, K., Yabuki, A., Kohyama, M., Kushida, K., Rahman, M.M., Uddin, M.M., Sawa, M., Yamato, O. : Molecular prevalence of multiple genetic disorders in Border collies in Japan and recommendations for genetic counselling. Vet J 214:21-3, 2016. Pubmed reference: 27387721. DOI: 10.1016/j.tvjl.2016.05.004.
Body/System/Process
Blood
OMIA Url
Inheritance
AR
HSP Test-Specific Data
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
FCI Number
297
GTP Breed
Border Collie
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
FCI Number
297
GTP Breed
Border Collie
The Kennel Club
GTP
GTP Name
The Kennel Club
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
This test is outsourced to:
Weatherby's
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
FCI Number
297
GTP Breed
Border Collie
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
FCI Number
297
GTP Breed
Border Collie
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
FCI Number
297
GTP Breed
Border Collie
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
VPS13B
Mutation
c.2893_2896del
Mutation Comment
g.1412654_1412657del
Nature of test
mutation test
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Embark
GTP
GTP Name
Embark
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
FCI Number
297
GTP Breed
Border Collie
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Nature of test
mutation test
GTP- or Breed-Specific Publications
Shearman J.R. and A.N. Wilton. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics 2011 12:258.
Application in the Breed
Carriers may be bred to normal animals (N/tns x N/N). Offspring should be tested before breeding. No breeding of two carriers (N/tns x N/tns) nor of affected animals (tns/tns). Elongated, ferret shaped skull and smaller than littermates. Immune system compromised (chronic infections)
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
297
GTP Breed
Border Collie
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
VPS13B
Mutation
g.4411950_4411953delGTTT
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