Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!

Donate

Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
WATCH NOW: Full video from recent webinar - "Breeding Healthy, Quality Dogs: The Veterinarian, Breeder, and Public Roles" w/ Jerold S Bell, DVM ×

Coat Colour Panda White Spotting

Breed: German Shepherd Dog/ Double coat

Generic Phene Data

Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
ALL
GTPs
Agrotis S.r.l.
BioBank AS
Certagen GmbH
CMSCH
Genomia s.r.o
INNO
Laboklin Gmbh & Co. KG
Laboratorios Labocor S.L.
PharmaDNA
Progènes-ADN
VHL Genetics
Zoolyx
AnimaLabs

General

Disease Name
Coat Colour Panda White Spotting
OMIA
1737
Gene Name
KIT
Mutation
c.1960_1962delCTC
Mutation 2
p.Leu654del
Test Type
Other Genetic Traits
Details
The Panda coat pattern is characterized by symmetrical markings of white forelock, chest, abdomen, collar, muzzle, and tip of the tail. The amount of white can vary. In the homozygous state (2 copies of the mutation), the Panda mutation is considered embryonic lethal as no live dogs with the pattern and with 2 copies of the mutation have been observed. Heterozygous (1 copy of the mutation) dogs do not have any reported health defects associated with this coat pattern.
Details 2
Variable degree of white spotting ranging from tiny white spots up to completely white animals. The absence of pigment is caused by the absence of skin melanocytes. The white-spotting allele appears to be autosomal dominant with respect to coat colour and recessive lethal.
Published
Wong, A.K., Ruhe, A.L., Robertson, K.R., Loew, E.R., Williams, D.C., Neff, M.W. : A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs. Anim Genet 44:305-10, 2013. Pubmed reference: 23134432. DOI: 10.1111/age.12006.
Published 2
Gerding, W.M., Akkad, D.A., Epplen, J.T. : Spotted Weimaraner dog due to de novo KIT mutation. Anim Genet 44:605-6, 2013. Pubmed reference: 23659249. DOI: 10.1111/age.12056.
Body/System/Process
Coat Colour/Pattern/Type
Inheritance
AD

HSP Test-Specific Data

Agrotis S.r.l.

GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

BioBank AS

GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Certagen GmbH

GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

CMSCH

GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Genomia s.r.o

GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
Panda White Spotting
Gene Name
KIT
Mutation
c.140_141insA
Mutation Comment
g.47144513_47144514insA

INNO

GTP
GTP Name
INNO
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Laboratorios Labocor S.L.

GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Laboklin Gmbh & Co. KG

GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Nature of test
mutation test
FCI Number
166

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Progènes-ADN

GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

VHL Genetics

GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

Zoolyx

GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del

AnimaLabs

GTP
GTP Name
AnimaLabs
Breed
OMIA
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.

  I accept