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Coat Colour Panda White Spotting
Breed: German Shepherd Dog/ long and harsch outer coat
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
General
Disease Name
Coat Colour Panda White Spotting
OMIA
1737
Gene Name
KIT
Mutation
c.1960_1962delCTC
Mutation 2
p.Leu654del
Test Type
Other Genetic Traits
Details
The Panda coat pattern is characterized by symmetrical markings of white forelock, chest, abdomen, collar, muzzle, and tip of the tail. The amount of white can vary. In the homozygous state (2 copies of the mutation), the Panda mutation is considered embryonic lethal as no live dogs with the pattern and with 2 copies of the mutation have been observed. Heterozygous (1 copy of the mutation) dogs do not have any reported health defects associated with this coat pattern.
Details 2
Variable degree of white spotting ranging from tiny white spots up to completely white animals. The absence of pigment is caused by the absence of skin melanocytes. The white-spotting allele appears to be autosomal dominant with respect to coat colour and recessive lethal.
Published
Wong, A.K., Ruhe, A.L., Robertson, K.R., Loew, E.R., Williams, D.C., Neff, M.W. : A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs. Anim Genet 44:305-10, 2013. Pubmed reference: 23134432. DOI: 10.1111/age.12006.
Published 2
Gerding, W.M., Akkad, D.A., Epplen, J.T. : Spotted Weimaraner dog due to de novo KIT mutation. Anim Genet 44:605-6, 2013. Pubmed reference: 23659249. DOI: 10.1111/age.12056.
Body/System/Process
Coat Colour/Pattern/Type
OMIA Url
Inheritance
AD
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Nature of test
mutation test
FCI Number
166
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
VHL Genetics/ Combibreed
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
KIT
Mutation
c.1960_1962delCTC; p.Leu654del
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