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Coat Colour, Dominant Black
Breed: ALL
Generic Phene Data
Breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
GTPs
General
Disease Name
Coat Colour, Dominant Black
OMIA
1416
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Test Type
Other Genetic Traits
Details
The K locus, or Dominant Black, refers to testing for the K-locus. There are a number of factors for determining a dog's visible (phenotype) coat colour and pattern, as many genes are involved to create a dog's coat. Within the K locus options include: dominant black - where a dog has inherited at least one K gene, will be solid black, (Kk, KK), kk can show tan markings, kbr - brindle, k - recessive non-black. Dominant black dominates the whole of the A locus, but it can be modified by other genes, such as liver, dilution, greying and merle. That black coat can then be changed to liver, blue, isabella or merle. The K locus plays a pivotal role in coat color. This locus is a relative newcomer in our understanding of canine color, and includes traits formerly attributed by some to other genes.
Details 2
The K locus, or Dominant Black, refers to testing for the K-locus. There are a number of factors for determining a dog's visible (phenotype) coat colour and pattern, as many genes are involved to create a dog's coat. Within the K locus options include: dominant black - where a dog has inherited at least one K gene, will be solid black, (Kk, KK), kk can show tan markings, kbr - brindle, k - recessive non-black. Dominant black dominates the whole of the A locus, but it can be modified by other genes, such as liver, dilution, greying and merle. That black coat can then be changed to liver, blue, isabella or merle. The K locus plays a pivotal role in coat color. This locus is a relative newcomer in our understanding of canine color, and includes traits formerly attributed by some to other genes.
Published
Candille, SI., Kaelin, CB., Cattanach, BM., Yu, B., Thompson, DA., Nix, MA., Kerns, JA., Schmutz, SM., Millhauser, GL., Barsh, GS. : A {beta}-Defensin Mutation Causes Black Coat Color in Domestic Dogs. Science 318:1418-23, 2007. Pubmed reference: 17947548. DOI: 10.1126/science.1147880.
Published 2
Kerns, JA., Cargill, EJ., Clark, LA., Candille, SI., Berryere, TG., Olivier, M., Lust, G., Todhunter, RJ., Schmutz, SM., Murphy, KE., Barsh, GS. : Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics 176:1679-89, 2007. Pubmed reference: 17483404. DOI: 10.1534/genetics.107.074237.
Published 3
Oguro-Okano, M., Honda, M., Yamazaki, K., Okano, K. : Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs. J Vet Med Sci 73:853-8, 2011. Pubmed reference: 21321476.
Body/System/Process
Coat Colour/Pattern/Type
OMIA Url
Inheritance
AD
HSP Test-Specific Data
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Nature of test
mutation test
GTP- or Breed-Specific Publications
Candille Sophie I, C B Kaelin et al. A beta-defensin mutation causes black coat color in domestic dogs. Science 318, 1418 (2007) DOI: 10.1126/science.1147880
FCI Number
-20
GTP Breed
ALL
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Nature of test
mutation test
FCI Number
-20
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Nature of test
mutation test
FCI Number
-20
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
c.231_233del
Mutation Comment
g.58965449_58965451del
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
-20
GTP Breed
ALL
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
GTP Disease Name
K Locus (Dominant Black)
Gene Name
CBD103
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
CBD103
Mutation
A 3-base pair (bp) deletion in the second exon of CBD103
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