Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!

Donate

Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
WATCH NOW: Full video from recent webinar - "Breeding Healthy, Quality Dogs: The Veterinarian, Breeder, and Public Roles" w/ Jerold S Bell, DVM ×

Narcolepsy

Breed: Australian Labradoodle

Generic Phene Data

Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
GTPs
Agrotis S.r.l.
BioBank AS
Certagen GmbH
CMSCH
DNA My Dog
Genomia s.r.o
INNO
Laboratorios Labocor S.L.
Orivet Genetic Pet Care
Paw Print Genetics
PharmaDNA
Progènes-ADN
VetGen LLC
VHL Genetics
Zoolyx

General

Disease Name
Narcolepsy
OMIA
703
Gene Name
HCRTR2
Gene Name 2
CanFam 3.1, Chr. 12
Mutation
c.1103+5G>A
Mutation 2
c.160G>A
Mutation 3
c.647-35ins226bp
Mutation 4
g.22620881G>A
Mutation 5
c.1105+5G>A
Test Type
Genetic Disease/Disorder
Details
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be very distressing for owners.
Details 2
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be distressing for owners.
Patents/ Licences
US20050048538 A1
Published
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Published 2
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, pg 531, 2001) Genome Research 11:919, 2001.
Published 3
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Body/System/Process
Neurologic
Inheritance
AR

HSP Test-Specific Data

VHL Genetics

GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

Zoolyx

GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

DNA My Dog

GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, p
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
-28
GTP Breed
Australian Labradoodle

CMSCH

GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

Progènes-ADN

GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

Paw Print Genetics

GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
FCI Number
-28

VetGen LLC

GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

INNO

GTP
GTP Name
INNO
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

Genomia s.r.o

GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1105+5G>A
Mutation Comment
g.22620881G>A

Orivet Genetic Pet Care

GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, p
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
FCI Number
-28
GTP Breed
Australian Labradoodle

Agrotis S.r.l.

GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

BioBank AS

GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

Laboratorios Labocor S.L.

GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A

Certagen GmbH

GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.

  I accept