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Narcolepsy
Breed: Labrador Retriever
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
GTPs
General
Disease Name
Narcolepsy
OMIA
703
Gene Name
HCRTR2
Gene Name 2
CanFam 3.1, Chr. 12
Mutation
c.1103+5G>A
Mutation 2
c.160G>A
Mutation 3
c.647-35ins226bp
Mutation 4
g.22620881G>A
Mutation 5
c.1105+5G>A
Test Type
Genetic Disease/Disorder
Details
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be very distressing for owners.
Details 2
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be distressing for owners.
Patents/ Licences
US20050048538 A1
Published
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Published 2
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, pg 531, 2001) Genome Research 11:919, 2001.
Published 3
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Body/System/Process
Neurologic
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, p
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1105+5G>A
Mutation Comment
g.22620881G>A
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
Point Mutation
Nature of test
mutation test
FCI Number
122
GTP Breed
Labrador Retriever
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A; c.160G>A
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Embark
GTP
GTP Name
Embark
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.1103+5G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (o
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Narcolepsy (Labrador Retriever Type)
Gene Name
HCRTR2
Mutation
c.160G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, p
Application in the Breed
Carriers may be bred to normal animals (N/nar x N/N) . Offspring should be tested before breeding . No breeding of two carriers (N/nar x N/nar) nor of affected animals (nar/nar). Sleepy during the day, drop suddenly from wakefulness into REM sleep, and can become cataleptic when startled
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
122
GTP Breed
Labrador Retriever
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