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Narcolepsy
Breed: Standard Dachshund/ longhaired
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
GTPs
General
Disease Name
Narcolepsy
OMIA
703
Gene Name
HCRTR2
Gene Name 2
CanFam 3.1, Chr. 12
Mutation
c.1103+5G>A
Mutation 2
c.160G>A
Mutation 3
c.647-35ins226bp
Mutation 4
g.22620881G>A
Mutation 5
c.1105+5G>A
Test Type
Genetic Disease/Disorder
Details
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be very distressing for owners.
Details 2
Narcolepsy causes extreme sleepiness in dogs. Signs include: dogs unable to maintain long stretches of wakefulness, falling asleep faster than normal dogs, buckling of hind legs and dropping neck (cataplexy) in response to positive stimui (such as treats). Age of onset from 4 weeks - 6 months. Narcolepsy is not considered progressive or life-threatening. However, attacks of cataplexy can be distressing for owners.
Patents/ Licences
US20050048538 A1
Published
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Published 2
Hungs, M., Fan, J., Lin, L., Lin, X.Y., Grigoriadis, D., Maki, R.A., Mignot, E. : Identification and functional analysis of mutations in the hypocretin (Orexin) genes of narcoleptic canines (vol 11, pg 531, 2001) Genome Research 11:919, 2001.
Published 3
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X.Y., Qiu, X.H., de, Jong, P.J., Nishino, S., Mignot, E. : The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98:365-376, 1999. Pubmed reference: 10458611.
Body/System/Process
Neurologic
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
Gene Name
HCRTR2
Mutation
c.160G>A
Mutation Comment
g.22517939G>A
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